Scientists have found that sperm from diabetic men have greater levels of DNA damage than sperm from men who do not have the disease. They warn that such DNA damage might affect a man's fertility.

In the first study [1] to compare the quality of DNA in sperm from diabetic and non-diabetic men, the researchers from Belfast, Northern Ireland showed that the DNA in the nuclei of the sperm cells had greater levels of fragmentation in diabetic men (52 percent, versus 32 percent in non-diabetic men), and that there were more deletions of DNA in the tiny, energy-generating structures in the cells called mitochondria (4 versus 3).

Dr Ishola Agbaje, who undertook the research published online today (Thursday 3 May) in the journal Human Reproduction, said: "As far as we know, this is the first report of the quality of DNA in the nucleus and mitochondria of sperm in diabetes. Our study identifies important evidence of increased DNA fragmentation of nuclear DNA and mitochondrial DNA deletions in sperm from diabetic men. These findings cause concern, as they may have implications for fertility."

The incidence of type 1 and type 2 diabetes is increasing rapidly worldwide. While diet and obesity are known to be key factors in the increase of type 2 (or late onset) diabetes, type 1 diabetes which is usually diagnosed in childhood or adolescence, is increasing by three per cent a year in European children, although the reason for this is not entirely clear. Genetic factors that make people more susceptible, or environmental factors such as viruses that may trigger the onset of type 1 diabetes, could play a role.

Dr Agbaje, a research fellow in the Reproductive Medicine Research Group at Queen's University, Belfast, said: "If the increasing trend in the incidence of type I diabetes continues, this will result in a 50 percent increase over the next ten years. As a consequence, diabetes will affect many more men prior to and during their reproductive years. Infertility is already a major health problem in both the developed and developing world, with up to one in six couples requiring specialist investigation or treatment in order to conceive. Moreover, the last 50 years have seen an apparent decline in semen quality. Sperm disorders are thought to cause or contribute to infertility in 40-50 percent of infertile couples. The increasing incidence of systemic diseases such as diabetes may further exacerbate this decline in male fertility. However, it is not clear to what extent clinics consider information about the diabetic status of their patients when investigating fertility problems." [2]

Dr Agbaje and his colleagues examined sperm from 27 diabetic men, with an average age of 34, and 29 non-diabetic men with an average age of 33. They found that although semen volume was significantly less in diabetic men (2.6 versus 3.3 ml), there were no significant differences in sperm concentration, total sperm output, form and structure of the sperm or their ability to move. When they measured DNA damage they found that the percentage of fragmented nuclear DNA was significantly higher in sperm from the diabetic men and that the number of deletions in mitochondrial DNA was also higher – the number of deletions ranged from three to six (average four) in the diabetic men and from one to four (average three) in the non-diabetic men.


Professor Sheena Lewis, scientific director of the Reproductive Medicine Research Group, said: "Our study shows increased levels of sperm DNA damage in diabetic men. From a clinical perspective this is important, particularly given the overwhelming evidence that sperm DNA damage impairs male fertility and reproductive health. Other studies have already shown that, while the female egg has a limited ability to repair damaged sperm DNA, fragmentation beyond this threshold may result in increased rates of embryonic failure and pregnancy loss. In the context of spontaneous conception, sperm DNA quality has been found to be poorer in couples with a history of miscarriages."

However, Prof Lewis said that it was not possible to say from this current study whether the DNA damage caused by diabetes would have the same effect on men's fertility and the health of future children as DNA damage caused by other factors such as smoking.

"This is just one, relatively small study that highlights a possible concern. Further studies need to be carried out in order to understand the precise nature of the diabetes-related damage, the causal mechanisms and the clinical significance. Given the global rise in the prevalence of diabetes, it is also vital to examine the reproductive outcomes of pregnancies fathered by diabetic men, and the prevalence of diabetes amongst men attending for infertility treatment," she concluded.

Tags: dna sperm

recommended for you


andytmi November 19, 2014
锘縜ctually rapidly, and as I'm depleted the entrance some sort of police force car or truck arrived through so i flagged the pup down."Police explained we were holding outside the church since police officers has actually been looking for a person along with Alzheimer ailment that received came down."They counseled me here in just five minutes,In Sorozan claimed.In addition, police arrest made it possible to find the guy they had been in the beginning searching for as soon as they were definitely flagged straig<a href=>air max 95 360 black blue</a>ht down by simply Sorozan.Community center officials mentioned imagine many of the things which the two brothers attempted to gain access to are already retrieved. Alternatives destroyed house windows, they price the item planning to consider pertaining to $1,500 to solve these.閿樼笅astor Tony a2z Evans brings major Power The afternoon meal target market

Onlookers of just about 500 consumers located discover Tony morrison Evans, mature minister at Oak High cliff Somebody Fellowship together with distributed radio stations broadcaster, at the To locate Power Lunch for the Initially Baptist Community center of Conroe for Monday.

"Kingdom individual can be every last person's fortune when he comes after spiritual rules every female's wish,Half inch stated Evans. "It's the aim of individual to live on their lifetime, his particular life insurance coverage, answerable to Goodness.In

Evan's thought to many individuals make an effort to compartmentalize their very own resides, sticking with God's statement several of the skill and placing it all to one side during many others. This kind of bifurcated located will cause disorder.

"A legitimate innovator proves her trust overall issues with lifetime,In . claimed Evans. "He is really a residing example for other people as well as usually takes liability for their activities and others for whom he's dependable.Half inch

Passing the buck to many others is certainly does not decrease task, he said.

"Coaches will not open fire competitors,Half inch claimed Evans. "They flames instructors.Half inch

Evans scalps any In search of,Five hundred fellow member Maple Ledge Bible Fellowship in Dallas, texas set up within 1976. He could be at the same time originator together with leader in the City Substitute, a nationwide corporation which wishes to produce non secular revival during downtown The usa through<a href=>air max thea atomic pink uk</a> the community center.

His / her radio station over the air, "The Solution with Dr .. Tony adamowicz Evans,In . are usually heard on over Five-hundred stores everyday all over America also in over 45 places.

Evans is known to enormous amounts as being a active plus charismatic public speaker who is spiritual play

<a href=>air jordan 1 1985 for sale</a>
<a href=>nike air max skyline black white</a>
<a href=>Moncler Jas Dames Jassen zwart 1678 Nieuwste Verkoop Online</a>
<a href=>nike free run youth blue chill</a>
<a href=>air jordan retro size 7 youth</a>
carpinteyrofmc November 15, 2014
锘縧dren's Healthcare facility inside Missouri.

Specialists state when young children aren't getting enough slumber, don't have enough time for you to accomplish research, and have absolutely simply no free time, it is time to reduce exercises. Take legal action against Kelly states she actually is continually viewing to assure the girl children's life is balanced, regardless of whether they're hectic.

A statement directed at a North american Academia of Pediatrics claims methodized actions will be advantageous, yet must not be thought of necessary for kids to formulate into effective adults.閿樼笂verseas Ownership Potential issues

Most in-demand StoriesMost Preferred StoriesMore>>Bond reduced intended for ex- Chilton State education member of staff involved in intercourse crimesBond decreased intended for ex- Chilton State college staff arrested for intercourse crimesUpdated: Friday, August Twenty-eight This year 16:20 In the afternoon EDT2014 35 Of sixteen:Twenty five:55 GMTThe female and also the woman's man ended up being arrested a few months ago during link to 87 gender criminal offense charges involving kids.The lady and the woman man ended up charged trapped on video tape during link to Eighty seven love-making crime rates relating to children.One hurt in Ensley service station photograph outOne seriously injured during Ensley service station capture outUpdated: Thurs ., July Twenty eight This year A few:14 In the afternoon EDT2014 2009 35 25:Twelve:Thirty eight GMTOne person photo at Gathering gas station throughout Ensley ThursdayOne person ended up being taken up a hospital, after a claimed fire outside in Birmingham.Someone seemed to be transported to a healthcare faci<a href=>air jordan xvi archives</a>lity, after having a reported blast outside Greater london.10 Researches: A Wie Glaciers Bucket Problem Controversy13 Looks into: A Wie Glaciers Suitable container Concern ControversyUpdated: Thursday, June 35 2014 15:41 Have always been EDT2014 The year 2008 Twenty eight 15:Forty one:04 GMTDr. Andrew d California king is really a mental problems examiner at UAB. He or she hope his research can result in a healthier way to identify Wie and learn what causes it.A lot more than 94 thousand as well as going up the. that is definitely simply how much this Wie Organization has got gathered looking at the viral ice container difficult task. Time adjustments everyday. Any its polar environment bucket struggle is just not for anyone and a few differ it is possible to give away your cash.Above Ninety four thousand and mountaineering. that is what amount this ALS Correlation has obtained in the vir

<a href=>nike blazer mid rot</a>
<a href=>spanwomens nike dunk high</a>
<a href=>air max 90 scarpe</a>
<a href=>spannike air max 1mens</a>
<a href=>air jordan 5 '3lab5'</a>
carpinteyrojxf October 26, 2014
锘縢ned to be placed in various areas together with roles because of its capability to preserve dampness together with waters product with a number of directions.

"Our brand-new CMS2 supplies buyers anything needed inside a maritime loudspeakers in a single streamlined, effortless to perform procedure,In claimed Allen They would. Gharapetian, Vice President of promoting as well as System Planning for Clarion Company of America. "But, all of us developed the particular CMS2 along with expansion options and gratification in mind to let end users to make their unique customized audio tracks playing knowledge from water using touch screen phone on the web connectivity and all sorts of vital attributes, which include built in Wi-fi recipient for music mp3 exploding, built in world-wide AM/FM/weather band, satellite tv for pc radio station readiness, AUX advice RCA along with Hardware knowledge together with One particular,1c charging you.Inches

Clarion innovative CMS2 works with a Thirty-two tiny bit minuscule control coupled including a A number of.A single direct music model to provide high end overall performance along with major quality of sound. It's also loaded with Half a dozen stations <a href=>san francisco moncler </a> associated with RCA components from A pair of v each one featuring an excellent built in amp which continuously monitors the program to help maintain low distortions stages and also maximizes audio quality. The unit is likewise designed with one of the most superior wireless network on the web connectivity on the market today which include Bluetooth Several.3, showcasing CSR aptX sound recording codec, gives lossless, CD high quality music any time loading about Bluetooth.

Based inside Cypress, Florida, Clarion Corporation of America can be a additional connected with Okazaki, japan based mostly Clarion Denver colorado. Limited, which has been any merged subsidiary in the Hitachi Party due to the fact 2006. Clarion may be an international innovator throughout car audio and video and gadgets considering the fact that 1940. The provider is actually engaged in the studies, advancement, technological innovation, style, creation, sales and marketing regarding mobile or portable enjoyment, course-plotting, infotainment, verbal exchanges, security products and solutions for that motor vehicle, sea, camper, commercially made navy and industry areas. Clarion may be your recipient of numerous superiority prizes with regard to style and design, <a href=>moncler winter jackets women </a> development, aid, creation in addition to push

<a href=>moncler boots women </a>
<a href=>moncler sale authentic </a>
<a href=>moncler t shirts </a>
<a href=>moncler nevada boots </a>
<a href=>it moncler outlet </a>
carpinteyroyrd October 25, 2014
nd trapped myself playing on the electric guitar solo connected with an ancient Steely Bob track ("Do Them Again") and expressing a bit of prayer he / she will not acquire through to the<a href=>Womens Supra Shoes Gold White - online supra shoes</a> verse received resumed. In the direction of get rid of this discussion, Gurus your pet how a new arrangement is acknowledged, anf the husband explained, "Every morning we glance at one another plus express we not able to imagine the best way without problems it's. Any beneficial keeps increasing and also harmful is practically removed,Inch Proper rights explained, introducing Sean Crum on the in the area waitress or in addition to pasta site explained to your pet the r / c "hasn't adjusted through that will station" since greatest of the '60s, 1970's and also 1980s going enjoying.Radio and TV train station master Tale Communications' Q3 Return Springs up 48

Fable Devices (London stock exchange AMEX:SGA), a good transmitting company within Grosse Pointe Farms, Michigan, announced at this time that the 3rd district profit increased 44%, whipping analyzer objectives.To your thirdly 1 fourth, this company earned $3.6 000 0000, or maybe Eighty-four dollars for every watered down discuss, as compared with $2.Five trillion, or simply 50 nickels per diluted present, for the exact same phase a year ago. Sales with the fraction has been $32.8 thousand thousand, in place with $31.3 or more , 000, 000 for Q3 connected with The year just gone.The results overcom the particular envisioned 76 pennies regarding revenues regarding $32.Seven million.Pertaining to 86% involving lastly fraction sales began radio stations segment. The organization radio stations means features any 61 FM as well as Thirty Feel radio , Three point out radio cpa networks, Couple of town radio station communities, as well as 5 minimal strength telly gas stops.Besides radio stations, the company has the benefit of 5 television system routes. 3rd 1 fourth proceeds for any tv set portion totalled $4.7 million.With the first in search of several months involving money This year, the provider attained $10.Six million, as well as $2.Fifty for each diluted write about, in comparison with $4.Ten trillion, and also $1.15 each diluted write about, for any year ago time. Profit for your timeframe improved 5% year over year to $93.Seven million.At fraction stop, the organization got $15 thousand with working capital and also $94.5 various trillion during lasting unsecured debt.Despite whipping specialist prices, the firm gives you chop down Just one.3% that will trade during $21.80 adjusted 3:17 in the evening ET.Aggressive Shareholders North America Corporation, tradings as "Proactiveinvestors United states

<a href=>Supra Skytop Black Green - supra skytop i</a>
<a href=>Supra Skytop High Blue Black White - latest supra shoes</a>
<a href=>Cheap GUCCI scarlett stud interlocking G tote 269953 AA61T 2729</a>
<a href=>Cheap GUCCI Bright Bit 319795 Blue Patent Leather Top Handle Tote Bag On Sale</a>
<a href=>Cheap GUCCI craft tote 247209 F4CMG 1000</a>