New Research Shows That Many Women Who Have Systemic Lupus Erythematosus (SLE) Can Experience A Successful Pregnancy.

New research shows that many women who have systemic lupus erythematosus (SLE) can experience a successful pregnancy. Many women who have lupus have been told it's unwise to pursue pregnancy. However, that may not be the case.
New research shows that women who have systemic lupus erythematosus (SLE) can experience a successful pregnancy. Many women who have lupus have been told it's unwise to pursue pregnancy, according to Ivanhoe. However, that may not be the case. For the study, researchers evaluated 333 pregnant women who had lupus. The expecting women were part of a study that attempted to determine biomarkers that predicted poor pregnancy outcomes. The researchers, who included Jane Salmon, M.D., Collette Kean Research Chair at Hospital for Special Surgery in New York City, and Jill Buyon from New York University Medical Center, concluded that 80 percent of the expectant women with lupus had a "favorable pregnancy outcome." "There was a misconception, based on outdated experience, that women with lupus should not try to have children," said Dr. Salmon. "Now that our treatments are more effective and we have a better understanding of the disease, we can identify a window when pregnancy is safe and outcomes are good for mother and fetus." "Most women with stable lupus, defined as limited disease activity and no flares during the time of conception and the first trimester, had successful pregnancies," said Dr. Salmon. She is also the principle investigator of the PROMISSE Study. "We learn from these results that timing is a most important element for successful pregnancy in women with lupus and that avoiding pregnancy during periods of increased disease activity is essential." Other study findings:
  • 63 of the 333 women had poor outcomes
  • 10 percent experienced preeclampsia
  • 10 percent experienced mild or moderate flares at 20 weeks
  • 8 percent experienced flares at 32 weeks
  • 19 women experienced death of the fetus

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