Protein In Immune System May Be Cause
Stephen Tong and colleagues from Monash University, Melbourne, and University of New South Wales, Sydney, Australia, investigated whether MIC1 plays a part in maintaining pregnancy viability by comparison of concentrations between failed and successful pregnancies.
The investigators found that MIC1 concentrations were around a third lower among 100 women who went on to miscarry than 200 women who delivered normally (the control group). MIC1 concentrations were measured in blood taken in the first trimester of pregnancy (6 to 13 weeks). There was no difference in reduced MIC1 concentrations in relation to the timing of miscarriage, although in most cases low MIC1 concentrations preceded miscarriage by several weeks.
"If a causal link between low MIC1 and miscarriage is confirmed, then MIC1, or its synthetic analogues, might be useful in prevention of miscarriage," Tong says.