Pregnant women with hypertension who also have elevated blood uric acid levels may face an increased risk of complications that could be fatal for mother and baby, University of Pittsburgh researchers have found.
Reporting in the Oct. 27 online issue of Hypertension, a journal published by the American Heart Association, researchers note that the greatest risk of high blood pressure during pregnancy accompanies preeclampsia, a devastating disorder that affects some 5 percent of first pregnancies and is traditionally diagnosed by increased blood pressure and the presence of protein in the urine. The only effective treatment is immediate delivery, which, if too early, can pose risks to the fetus.

In developed countries where prenatal care is routine, preeclampsia accounts for about 15 percent of premature deliveries a year. Worldwide, in settings without good prenatal care, preeclampsia increases the risk of fetal death five-fold and kills 50,000 women a year, researchers said. For clinicians, treating preeclampsia is a delicate balance of fetal and maternal risk from the disease and fetal development-associated risk because of premature delivery.

"We used a research database to ask whether inclusion of uric acid levels in the diagnosis of preeclampsia would help us to evaluate risk for complications among patients," said James M. Roberts, M.D., professor and vice chair of research in the department of obstetrics, gynecology and reproductive sciences at the University of Pittsburgh School of Medicine and the study's first author. "We focused primarily on fetal outcomes such as gestational age at delivery and birth weight, but also looked at markers of maternal disease, including severely elevated blood pressure during labor."

Records for 972 pregnant women who were recruited between 1997 and 2002 as part of an ongoing preeclampsia study at the Magee-Womens Hospital of the University of Pittsburgh Medical Center were reviewed and the women were divided into eight groups:

  • 431 women had normal levels of uric acid and blood pressure and no evidence of protein in their urine
  • 48 women had classic preeclampsia including high blood pressure and protein in their urine but normal uric acid
  • 141 women had preeclampsia and elevated levels of uric acid in their blood
  • 52 women had high blood pressure and elevated levels of uric acid but no protein in their urine
  • 184 women had only increased uric acid levels
  • 83 women had only high blood pressure
  • 21 women had only protein in their urine
  • 12 women had protein in their urine and elevated levels of uric acid but normal blood pressure

    Analysis of the data revealed that the women with both preeclampsia and elevated uric acid levels had a nearly seven-fold increased risk of premature delivery and delivered nearly four weeks earlier than preeclamptic women whose uric acid levels were normal. Most of these deliveries were induced to prevent more severe maternal illness and infants tended to be smaller at birth, even adjusted for gestational age, Dr. Roberts said.

    One of the more interesting findings was that for women with high blood pressure and no protein in their urine but who did have increased uric acid, the risk of early delivery or reduced fetal growth was at least as likely as in women with classic signs of preeclampsia but normal uric acid. Also, women with high blood pressure who lacked urine protein and had normal uric acid had no increased risk for babies.

    "Irrespective of protein levels, women with high blood pressure had a higher incidence of being delivered early as uric acid increased," said Dr. Roberts, who also is director of the university-affiliated Magee-Womens Research Institute. "For every one-unit increase in uric acid, the odds of preterm birth increased 2.3 times."

    While results of the National Institutes of Health-funded study seem to suggest that uric acid measures could have a utility for predicting risk of adverse outcomes, further prospective testing is necessary to confirm the findings and determine cost-effectiveness of its use to improve outcomes, Dr. Roberts said.

  • Tags: acid uric

    recommended for you


    carpinteyrouvi November 21, 2014
    锘縯hey 1st two batters while in the group, gotten to bottom together with members from the initially inning. Soon after not one but two outfield popups, old Phillies outfielder Bobby Abreu helped bring Adolescent home which includes a single, and also very first baseman Lucas Duda attack an RBI two bottle to own Mets a 2 0 cause.

    Mets eventually left hander Jake deGrom cruised throughout the Phillies' list away from the gateway. DeGrom's first three innings were definitely wonderful in addition to enclosed 6 strikeouts on 45 pitches the 1st time through the group.

    Kendrick calmed down inside the second along with lastly innings and also retired seven instantly hitters, yet Tejada's by yourself home run inside the fourth gave a Mets a good About three Zero advantage.

    Tejada smacked once more in the the top of 6th inning which has a one that scored Abreu and presented your Mets an<a href=>nike dunk low shoe silver white</a>y Five 5 lead. Tejada concluded A few with regard to 5 by using two RBIs, a pair of works and a couple walks.

    Kendrick concluded this 6th with all the 4 run shortage undamaged. Tony adamowicz Gwynn Junior. pinch click for Kendrick in the bottoom with the sixth just after Kendrick possessed helped ten strikes and 4 is run on 117 pitches.

    This Phillies broken any scoreboard in the bottoom with the in 7th place along with Howard's three work great hit that will quit arena so it will be a good 4 Several match. A attack heightened Howard to at least one,A thousand RBIs, producing swiftest lively gamer for this in barely 1,230 games.

    DeGrom regularity 7 1/3 innings together with granted a couple of visitors plus 3 functions while eye-catching out 11 her first two bottle number strikeout game while in the majors.

    Paperwork: Proceeding towards Saturday's game, the Mets got obtained A number of.78 runs in each recreation while travelling, finest the country's Group. Your Excellent, with 4.66, are usually secondly. . Inspite of the decline, the actual Phillies participate in their finest on the weekends. Chicago provides a 14 Your five record on Saturday and Sunday activities. . A Mets struck the highway typically with August, actively playing 3 of these subsequent 31 video games from the Citi Area. The big apple can be Couple of 1 in any middle of a period significant Eleven activity journey.閿樼笅hillies Five

    Although the scouts can take several days in order to complete their information, the fanatics will not need nearly so much time and energy to course of action your typically unsatisfying overnight in the ex- Cy Adolescent Give winn

    <a href=>air max 1 black volt liberty</a>
    <a href=>nike air max moto womens 8.5</a>
    <a href=>nike air max one femme orange</a>
    <a href=>Moncler Dames Hooded omlaag Coats Navy Lage Prijs Verkoop Winkel 2014</a>
    <a href=>Moncler Nantes Hooded Dames Long Down Jassen Coffee Lage Prijs Verkoop Winkel 2014</a>
    Joeslc November 16, 2014
    锘?brought $250,500 with a political stage board in which compared Dale re also election.

    A good reason Dale and Scruggs were definitely during probability seemed to be which Dale paid your mediation program intended for Typhoon Hurricane katrina anniversary passes subjects to end their particular boasts with insurers without having looking for lawsuit.

    Scruggs attorney manifested countless householders that charged his or her insurers more than not paid boasts once the weather ravaged this Beach Region with August. 29, 2006.

    Scruggs in addition declared Dale is for that insurance cover marketplace as to how you can manage all of them.

    Dale, america top servicing insurance protection commissioner, was basically selected around 1975. The actual Sixty six yr is usually a original high school graduation principal, that proved helpful for an asst . to get subsequently Gov. <a href=>nike air max classique</a>William Waller prior to he picked up election because insurance cover commissioner.

    Anderson, Fifty, exactly who made while fiscal police officer in after that Gov. Ronnie Musgrove by 2000 to 03, have been functioning their own government issues along with monetary asking business enterprise.

    Anderson had been generating his / her secondly function designed for state-wide place of work. With 2002, they seemed to be the actual Democratic nominee regarding express treasurer any time simply no obligatory was functioning. The guy missing to Republican Tate Reeves, the political beginner.閿樼釜thers in relation to helping Iraqi refugees

    ended up being taking up offers to enable those people who are under threat in the Qaida splinter group, this Islamic State of Irak and also the Levant.

    "We have got delivers associated with help with a wide variety of members just like England, Questionnaire, North america,Inches Rhodes said.

    "We'll wear chats with them by what they might complete both the way it works with improving the Yazidi population . called straight down targets it may well unveiling some<a href=>Moncler Heren omlaag Hooded Jassen Navy 1770 Nieuwste Verkoop Online</a> sort of relief vision. will to create a relief goal right now there.

    Hagel reported airdrops regarding water and food obtained continual the actual refugees knowning that airstrikes with militants had authorized many of them to flee any<a href=>2012 Nieuwe Moncler Epine Dames Down Jassen Zwart Lage Prijs Verkoop Winkel 2014</a> mountain / hill. authorities explained an examination staff possesses identified that just several thousand Iraqi refugees continue to your mountain. 1000's ended up documented certainly, there a while back. got moved up their Iraqi involvement during new nights, soon after hundreds and hundreds turned out to be caught on the runway to

    <a href=>Moncler Heren Down Jassen grijs 1824 Lage Prijs Verkoop Winkel 2014</a>
    <a href=>nike shox qualify 2011</a>
    <a href=>comprare nike blazer donna</a>
    <a href=>air jordan 13 'hornets'</a>
    <a href=>Moncler Dames Hooded omlaag Belt Jassen Navy 1332 Lage Prijs Verkoop Winkel 2014</a>
    henryfyp October 30, 2014
    st Siberian categories, mostly by way of new manufacturing technologies.

    "We will be looking at most of the solutions, besides providing resources that may not execute. Perform own instruments along with engineering to improve operation and then we can use these folks. We're also trying to possibly be careful and artistic about that which we is able to use concerning systems."Ross as well as Burbank

    Sept 7, The year 2013 An hour: 1Obama can be arguing to fight Syria. Because i am expect<a href=>supra foam shoes </a>ing Congress to help political election on this, most of us have with the distinctive attributes in i<a href=>supra skytop 2 grey </a>f we have to range in price up from Syria. Dude Particular person of your Right now Onlooker provides us your information to the Packers who will be trying to play this Seahawks. He said Portland is a great put plus the Seahawks a great group to pay. We have now Forty somethings going back, plenty of people will be switching property. The particular jobless is down because some people have provided high on selecting a work. Even though some may very well be very angry together with the incontrovertible fact that, it means the project undoubtedly two weeks guiding timetable, KIRO Radio's John Curley says no people must a little surprised. Listen closely Download

    September 35, The year 2013 Hour or so: 1Looking returning upon MLK ersus dream Listen Get a hold of

    Friday, July 30, The year 2013

    Aug 29, 2013 Hr: 1Four 100 law enforcement officers raid motels alongside Road 99Listen Get

    Mon, July 27, 2013

    Ken Schram: If you would like goat's, transfer to a new farmAfter experiencing of the Govt Manner 8th grader petitioning the city of Govt Option to reclassify goats mainly because place household pets in lieu of problems, KIRO Radio's Ken Schram had an advice: turn to any town. Listen DownloadRoss Bjork Titled Brand-new WKU Sports Representative

    Ross Bjork, who may have did wonders the previous 5 periods since the Mature Affiliate Fit Overseer regarding Growth as well as Alternative Contact on UCLA, is branded European Kentucky School's Producer of Activities, President Physician. Grettle Ransdell declared right now.

    Bjork offers Eighteen a lot of intercollegiate sports entertainment expertise being an supervisor together with individual sportsman, possessing likewise done anything about the person team members within the Institution with Finland and also the Univer

    <a href=></a>
    <a href=></a>
    <a href=></a>
    <a href=></a>
    <a href=></a>
    carpinteyrorjy October 27, 2014
    h a unique muscle mass. And you can view the contribute to affected individuals that have split the knee's anterior cruciate ligament.

    "It literally seems as if muscle has got kind of melted absent,In . he said. "So <we>think] when an individual utilised a good myostatin inhibitor briefly which may really be useful for avoiding the actual waste away at a later time.In .

    Another researchers wealthy in hopes for myostatin is certainly physiologist Lee Sweeney, who seem to tests muscle disorders along at the University or college connected with Pa. Nevertheless Sweeney's confidence around fresh solutions is usually tempered by just his / her worry about doping.

    Just about a decade ago, Sweeney composed articles with Methodical Usa alert that myostatin mau becomes a major symptom in sporting events. At that time, he or she thought some athletes might have gene remedy that will once and for all prohibit myostatin.

    Right now, he admits that, it appears as though myostatin blocking medicines can provide a less costly, less difficult plus more attractive possibility. For starters, Sweeney shows, the products may leave simply no search for when a player quits using them all.

    "They would've the limited form of time they will will live in your system and they might be cleared,In he said. "And so, as opposed to gene treatment, if you timed it appropriate you do not be capable to detect that were there recently been made use of.Half inch

    Sweeney dreads that myostatin medicines will become renowned doping real estate agents. Then simply, he tells, physicians may well be reluctant to be able to suggest these individuals with regard to legitimate takes advantage of, just like encouraging patients using most cancers or renal system disease that can will no longer walk mainly because they have forfeit a lot muscles.锘縉ew public recognizes Biloxi's sea food customs using Arena connected with Fame

    BILOXI, MS (WLOX) This end of the week a completely new establishing packed with Three hundred ages importance of Biloxi abundant seafoods and also historic background could open. Old testimonies shall be noticed together with found in are actu enactments, items and old snap shots. The newest facility changes the actual museum worn out by means of Storm Hurricane katrina anniversary passes.I was on the spot within the brand-new public, where the completing variations had been underway. Just some days to weeks quit prior to the opportunities within the 3 report, 20,A thousand square foot put togethergrams a unique muscles. And view the result in individuals who have broken any knee's anterior cruciate structures.

    "It honestly seems like the muscles has got kind of dissolved aside," according to him. "So <we>think] when anyone applied any myostatin inhibitor for a while that could be beneficial in stopping the particular waste away down the line.In

    An additional science tecnistions with high desires myostatin is certainly physiologist Lee Sweeney, which studies muscle mass diseases at the University or college with California. However Swee <a href=>moncler winter jackets women </a> ney's anticipation in relation to new cures is certainly tempered by means of his worry about doping.

    Pretty much ten years ago, Sweeney had written a write-up in Research United states warning that will myostatin mind games may be an enormous problems in sporting activities. Right at that moment, this individual imagined athletes may well undergo gene therapy in order to once and for all block myostatin.

    These days, according to, it appears that myostatin blocking medications will give you a less expensive, better and even more beautiful selection. For instance, Sweeney states that, the merchandise is likely to keep hardly any know as soon as a player ceases getting these people.

    "They may have any only a certain style of precious time which they would likely are in one's body and then they might be loosened,Inches he tells. "And and so, unlike gene treatments, should you timed them perfect you possibly will not be capable of diagnose that they been made use of.Half inch

    Sweeney concerns this myostatin drugs might be famous doping providers. Next, he said, general practitioners might think twice to help assign them all designed for legitimate uses, for instance serving individuals with most cancers as well as renal disorder that can no longer wander since they have got a lot of lean muscle.閿樼笁ew museum consistently improves Biloxi's bass culture using Arena of Fame and fortune

    BILOXI, MS (WLOX) This end of the week a whole new setting up stuffed with Three hundred years worth of Biloxi vibrant bass <a href=>moncler maya jacket </a> in addition to sea-loving heritage may amenable. Famous tales shall be listened to and affecting the type actu enactments, artifacts as well as old pictures. The fresh center switches the previous art gallery damaged through Typhoon Katrina.We were on the webpage with the completely new art gallery, in which the fini <a href=>moncler bomber jacket </a> shing meets ended up going ahead. Just a couple of days kept until the entry doors on the a couple of scenario, Twenty,1,000 square foot create

    <a href=>moncler polo uomo 2014 </a>
    <a href=>last season moncler </a>
    <a href=>moncler new season 2014 </a>
    <a href=>moncler bady hooded puffer jacket </a>
    <a href=>moncler leather jackets </a>
    henryzxa August 03, 2014