In developed countries where prenatal care is routine, preeclampsia accounts for about 15 percent of premature deliveries a year. Worldwide, in settings without good prenatal care, preeclampsia increases the risk of fetal death five-fold and kills 50,000 women a year, researchers said. For clinicians, treating preeclampsia is a delicate balance of fetal and maternal risk from the disease and fetal development-associated risk because of premature delivery.
"We used a research database to ask whether inclusion of uric acid levels in the diagnosis of preeclampsia would help us to evaluate risk for complications among patients," said James M. Roberts, M.D., professor and vice chair of research in the department of obstetrics, gynecology and reproductive sciences at the University of Pittsburgh School of Medicine and the study's first author. "We focused primarily on fetal outcomes such as gestational age at delivery and birth weight, but also looked at markers of maternal disease, including severely elevated blood pressure during labor."
Records for 972 pregnant women who were recruited between 1997 and 2002 as part of an ongoing preeclampsia study at the Magee-Womens Hospital of the University of Pittsburgh Medical Center were reviewed and the women were divided into eight groups:
Analysis of the data revealed that the women with both preeclampsia and elevated uric acid levels had a nearly seven-fold increased risk of premature delivery and delivered nearly four weeks earlier than preeclamptic women whose uric acid levels were normal. Most of these deliveries were induced to prevent more severe maternal illness and infants tended to be smaller at birth, even adjusted for gestational age, Dr. Roberts said.
One of the more interesting findings was that for women with high blood pressure and no protein in their urine but who did have increased uric acid, the risk of early delivery or reduced fetal growth was at least as likely as in women with classic signs of preeclampsia but normal uric acid. Also, women with high blood pressure who lacked urine protein and had normal uric acid had no increased risk for babies.
"Irrespective of protein levels, women with high blood pressure had a higher incidence of being delivered early as uric acid increased," said Dr. Roberts, who also is director of the university-affiliated Magee-Womens Research Institute. "For every one-unit increase in uric acid, the odds of preterm birth increased 2.3 times."
While results of the National Institutes of Health-funded study seem to suggest that uric acid measures could have a utility for predicting risk of adverse outcomes, further prospective testing is necessary to confirm the findings and determine cost-effectiveness of its use to improve outcomes, Dr. Roberts said.