Antibiotics In The First Six Months Of Life Studied
The study's findings are believed to be the first of its kind in the United States that found a link between antibiotics and allergies and asthma in children.
"I'm not suggesting children shouldn't receive antibiotics. But I believe we need to be more prudent in prescribing them for children at such an early age," says Christine Cole Johnson, PhD, the study's lead author and senior research epidemiologist for Henry Ford's Department of Biostatistics & Research Epidemiology. "In the past, many of them were prescribed unnecessarily, especially for viral infections like colds and the flu when they would have no effect anyway."
Johnson theorizes that use of antibiotics may affect the gastrointestinal tract and alter the development of a child's immune system.
The increasing use of antibiotics in children from 1977 to the early 1990s led to what federal health officials called a public health crisis in antibiotic resistance. A national campaign commissioned by the US Centers for Disease Control and Prevention has sought to promote a more judicious approach for prescribing antibiotics for children.
For the Henry Ford study, researchers followed 448 children from birth to seven years. The children were evenly divided by gender.
Data was collected prenatally and at the first four birthdays until the children were 6 and 7 years old, when they underwent a clinical evaluation by a board-certified allergist. The data included information about all prescribed oral antibiotics; blood tests that measure the antibody (immunoglobulin E) that causes allergies; and skin reaction tests that show whether a person is hypersensitive to an allergen. Researchers also collected data on all clinical visits and made home visits to collect environmental samples.
Of the 448 children, 49 percent had received antibiotics in the first six months of life. The most common antibiotic category prescribed was penicillin.
Among the findings: